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| INTRODUCTION |
Section
2 of 10
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Background: Salter-Harris fractures are fractures through
a growth plate; therefore, they are unique to pediatric patients. Several
types of fractures have been categorized by the involvement of the physis,
metaphysis, and epiphysis. The classification of the injury is important
because it affect the treatment of the patient and provides clues to
possible long-term complications.
Pathophysiology: The histologic
features of the physis are important for understanding the prognosis of
physeal fractures. The germinal layer of the cartilage is on the epiphysis
and derives nutrition from the epiphyseal vessels. Cartilage cells grow
from the epiphysis towards the metaphysis, forming columns of cells that
degenerate, fragment, and undergo hypertrophy. The fragments of cells
mineralize. This is the zone of provisional calcification forming the
metaphyseal border, and is not bone. Note that no circulation exists in
the cartilage zone.
Neovascularization occurs from the metaphysis towards
the epiphysis. Endothelial cells transform into osteoblasts and use the
degenerate cell debris to form primary immature bone. This immature bone
progressively is remodeled to mature woven bone and further is remodeled
by cutting cones to form mature haversian system bone. Damage to either
epiphyseal or metaphyseal vascular supply disrupts bone growth; however,
damage to the layer of cartilage may not be significant if the surfaces
are reapposed, and vascular supply to the growing cartilage is not
permanently interrupted. When the 2 vascular beds touch, the physis is
closed (fused) and no further bone growth is possible.
Age: Salter-Harris fractures are
injuries through the physis. Therefore, by definition, they must occur
before the physis closes. Typically, physis closure occurs during the
teenage years.
Clinical Details: The classification of
Salter-Harris fractures is used to describe the extent and site of the
epiphyseal injuries. The basic types of injuries include the following:
 | Type I
 | A type 1 fracture is transverse fracture through
the hypertrophic zone of the physis. In this injury, the width of
the physis is increased. The growing zone of the physis usually is
not injured, and growth disturbance is uncommon.
 | On clinical examination, the child has point
tenderness at the epiphyseal plate, which is suggestive of a type
I fracture. |
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 | Type II
 | A type II fracture is a fracture through the
physis and metaphysis, but the epiphysis is not involved in the
injury.
 | These fractures may cause minimal shortening;
however, the injuries rarely result in functional limitations.
 | Type II is the most common Salter-Harris
fracture. |
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 | Type III
 | A type III fracture is a fracture through the
physis and the epiphysis. This fracture passes through the
hypertrophic layer of the physis and extends to split the
epiphysis, inevitably damaging the reproductive layer of the
physis.
 | This type of fracture is prone to chronic
disability because, by crossing the physis, it extends into the
articular surface of the bone.
 | However, type III fractures rarely result in
significant deformity; therefore, they have a relatively favorable
prognosis.
 | A type of ankle fracture termed a Tillaux
fracture is a type of Salter-Harris type III fracture that is
prone to disability.
 | The treatment for this fracture often is
surgical. |
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 | Type IV
 | A Type IV fracture involves all 3 elements of the
bone: The fracture passes through the epiphysis, physis, and
metaphysis.
 | Similar to a type III fracture, a type IV
fracture also is an intraarticular fracture; thus, it can result
in chronic disability.
 | By interfering with the growing layer of
cartilage cells, these fractures can cause premature focal fusion
of the involved bone. Therefore, these injuries can cause
deformity of the joint. |
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 | Type V
 | A type V injury is a compression or crush injury
of the epiphyseal plate with no associated epiphyseal or
metaphyseal fracture.
 | This fracture is associated with growth
disturbances at the physis. Initially, diagnosis may be difficult,
and it often is made retrospectively after premature closure of
the physis is observed. In the older teenagers, the diagnosis is
particularly difficult.
 | The clinical history is paramount in the
diagnosis of this fracture. A typical history is that of an axial
load injury.
 | These injuries have a poor functional prognosis. |
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When all types of Salter-Harris fractures are
considered, the rate of growth disturbance is approximately 30%. However,
only 2% of Salter-Harris fractures result in a significant functional
disturbance.
Rare types of Salter-Harris fractures include the
following:
 | Type VI: This is a rare injury and consists of an
injury to the perichondral structures.
 | Type VII: This is an isolated injury to the
epiphyseal plate.
 | Type VIII: This is an isolated injury to the
metaphysis, with a potential injury related to endochondral
ossification.
 | Type IX: This is an injury to the periosteum that may
interfere with membranous growth. |
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Preferred Examination: Radiography
always is the preferred examination in a suspected fracture. The use of
another modality should not be considered until appropriate plain film
radiography has been performed.
In cases of severe injury in which the patient has acute
pain, appropriate radiographic examination of the involved area may be
difficult because of inadequate patient positioning. In these cases, CT
may be beneficial in evaluating the injury after a radiologist has
evaluated the plain radiographs. However, the cost of CT may prohibit its
use in all cases in which the area of interest is suboptimally evaluated.
CT should be considered only when radiographic findings are insufficient.
Typically, an orthopedic surgeon and a radiologist make the decision to
perform CT.
If an additional study is performed, its purpose is to
determine the appropriate management and assist in surgical planning.
Thus, the surgeon performing the operation is best suited to request the
imaging study. When further definition of fractures may help in making
management decisions or when the injury does not responding to
conservative management, the radiologist or orthopedic surgeon can
recommend an appropriate examination to perform after plain radiography.
Currently, 2 radiologic examinations can be performed to
further evaluate fractures: (1) CT with multiplanar reconstruction and (2)
MRI. MRI depicts marrow edema, whereas CT shows cross-sectional bone
detail and tomographic multiplanar information. The use of MRI in the
evaluation of fractures is described below, but it is still in its
infancy. At the present time, MRI is not the standard of care. CT is used
more commonly; typically, it is used for planning surgery.
Limitations of Techniques: The primary
disadvantages of MRI are related to its expense, time requirement, and
availability, which limit the routine use of MRI. As techniques and
software improve, the use of MRI in the acute trauma setting is likely to
increase.
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DIFFERENTIALS |
Section
3 of 10
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Ankle, Fractures
Elbow Trauma -
Pediatric
Wrist, Scaphoid
Fractures and Complications
Findings: X-ray findings vary according
to the type of Salter-Harris fracture.
With type I fractures, initial radiographs may suggest
separation of the physis, but this separation may not be apparent.
However, soft tissue swelling is present, and its center typically
overlies the physis (see Image 2). Follow-up
radiographs obtained 7-10 days after injury help in establishing the
diagnosis. New bone growth (ie, adjacent sclerosis and periosteal
reaction) along the epiphyseal plate confirms the diagnosis of a
Salter-Harris type I fracture.
In type II fractures, the fracture line passes through
the metaphysis into the epiphyseal plate, but no fracture is observed in
the epiphysis (see Image 3). The metaphyseal
fragment is sometimes called the Thurston-Holland fragment.
Type III fractures pass through the hypertrophic layer
of the physis and extend to split the epiphysis (see Image
4). The fracture crosses the physis and extends into the articular
surface of the bone.
Type IV fractures pass through the epiphysis, physis,
and metaphysis (see Image 5). Similar to a type III
fracture, a type IV fracture also is an intraarticular fracture.
In type V injuries, initial plain radiographs may not
show a fracture line, similar to images of type I fractures (see Image
6). However, soft tissue swelling at the physis is present. A
compression or crush injury of the epiphyseal plate is present without
associated epiphyseal or metaphyseal fracture
Findings: CT has an
important role in the evaluation of epiphyseal injuries. Rogers and
Poznanski discussed the role of CT with the use of a bone algorithm and
multiplanar reconstruction of multiplanar initial images. With CT, a
considerable amount of information regarding the nature of the fracture
can be gathers. CT techniques typically are used in patients prior to
surgery, after a fracture is diagnosed on the basis of plain radiographic
findings.
Multiplanar CT findings are similar to
plain radiographic findings.
Degree of Confidence: The
computer program is able to compensate for imprecise patient positioning.
True lateral and true anteroposterior (AP) views of the bone in question
can be obtained. As with any study, physicians who request these costly
studies should have the knowledge and experience needed to interpret the
images. Orthopedic surgeons may be the ones to request CT examinations;
however, any physician can order them in consultation with a radiologist.
The advantage of CT compared with MRI is
its availability and the speed with which images can be obtained. The
disadvantage is that CT requires a relatively large dose of radiation for
diagnostic imaging. Raw-data images typically are obtained with 1-mm
sections and a high milliampere technique; however, the high collimation
reduces the total amount of exposure.
In the near future, multi–detector row
technology is likely to affect the utility of CT in the detailed
evaluation of fractures.
Findings: On MRIs, the
typical findings of Salter-Harris fractures include a signal void on
T1-weighted images. On T2-weighted images, increased signal intensity,
which is consistent with edema, is depicted around the fracture site.
MRI is used for surgical planning. Craig
et al discussed the use of MRI in evaluating partial closure of the growth
plates. Patients with functional or growth abnormalities were examined
with MRI, and the exact nature of the defects were well described. These
findings helped orthopedic surgeons to plan appropriate surgery.
Currently, no imaging technique is
recommended and uniformly accepted for use in the evaluation of a
Salter-Harris injury in children. However, from data in this section, one
could conclude that MRI with multiple sequences provides more information
than MRI with a single sequence. Thus, T1-weighted, T2-weighted, and
gradient-echo imaging without contrast enhancement can be used to evaluate
the bony structures, soft tissue, and physis well.
In a recent article, Craig et al
suggested that a sagittal 3-dimensional (3D) spoiled gradient-recalled (SPGR)
sequence is the best sequence for the evaluation of the physeal plate.
(According to the article, this sequence is widely available.) Craig et al
examined 22 patients with this sequence and claimed that this sequence
provided excellent detail of the physeal plate. In addition to the SPGR
sequence, they used 2-dimensional (2D) sagittal and coronal fast spin-echo
sequences with an echo train length of 3 and 3-mm-thick sections with a
1-mm gap. The field of view was 14 cm. They also used 2D axial and coronal
fast spin-echo imaging with fat saturation, an echo train length of 8, and
5-mm-thick sections with a 1.5-cm gap. The field of view was 18 cm.
If findings from the cited articles are
compared, the use of a single sequence does significantly decrease the
imaging time; in children examination time is an important factor.
However, Craig et al strongly argues that SPGR provides the best images of
the physis. To the author’s knowledge, no group has used SPGR alone in
the examination of children with trauma. Again, the evaluation of
Salter-Harris injuries in children is a new use of MRI technology, and no
standard is uniformly accepted at this time.
Degree of Confidence: MRI
is a relatively new technique. MRI is limited in the assessment of acutely
injuries because of the length of time involved in the examination.
Another limitation is the relative isolation of the patient within the
machine.
Currently, MRI has limited utility in
the evaluation of Salter-Harris fractures. Therefore, it is most
efficiently applied by specialists with specific treatment questions.
Orthopedic surgeons are the most appropriate physicians to request MRI;
however, in consultation, a radiologist and a clinician may determine a
specific need for MRI findings in a given case. Consultation with an
orthopedic surgeon is likely to be helpful in complicated injuries that
require treatment.
MRI in the setting of acute trauma has
been discussed in 2 recent articles. Close and Strouse retrospectively
evaluated 315 consecutive knee MRI in children with a history of trauma.
They reported that MRI revealed several additional fractures that were not
fully identified on plain radiographs, and, of the 8 fractures found with
MRI, 7 had findings that changed the clinical management. This study was
limited because of its retrospective nature and selection bias; however,
the authors indicate that MRI is better than plain radiography in
delineating the exact nature of an injury. In complex cases, this
advantage may be of clinical importance.
False Positives/Negatives: Carey
et al reviewed the correlation of MRI results and plain radiographic
findings in Salter-Harris fractures and found a trend similar to that of
Close and Strouse. In 2001, a Finnish study revealed no misclassification
in patients with minor ankle fractures; MRI was helpful in evaluating
complex injuries in the ankle.
A study performed in 1996 by Petite et
al revealed a small benefit with the use of MRI versus plain radiography
They found a misclassification rate of only 3% in patients with acute
trauma. This study was limited because only gradient-echo imaging was
used. Carey et al and Close and Strouse used multiple MRI techniques. The
conclusion of Petite et al is similar to that of the other studies: MRI
can be helpful in complex cases or when plain radiographic findings are
normal and the clinical findings are highly suggestive of fracture.
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ULTRASOUND |
Section
7 of 10
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Findings: Ultrasonography
(US) has a limited role in the diagnosis of fractures.
Degree of Confidence: In
a recent study, Hubner et al compared the results of primary US diagnosis
of fractures with the results of plain radiography. They were able to
accurately diagnose fractures with US; however, complex fractures were
more difficult to assess with US. Salter-Harris type I fractures and
nondisplaced fractures with less than 1 mm of separation were reliably
detected with US.
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NUCLEAR
MEDICINE |
Section
8 of 10
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Findings: Although
nuclear medicine studies had a role in the diagnosis of Salter-Harris
fractures in the past, MRI and CT have replaced nuclear medicine study in
the evaluation of subtle fractures.
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BIBLIOGRAPHY |
Section
10 of 10
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Brown JH, DeLuca SA: Growth plate
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Carey J, Spence L, Blickman H,
Eustace S: MRI of pediatric growth plate injury: correlation with
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27(5): 250-5[Medline]. |
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Close BJ, Strouse PJ: MR of physeal
fractures of the adolescent knee. Pediatr Radiol 2000 Nov; 30(11):
756-62[Medline]. |
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Craig JG, Cramer KE, Cody DD:
Premature partial closure and other deformities of the growth plate:
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835-43[Medline]. |
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Hubner U, Schlicht W, Outzen S, et
al: Ultrasound in the diagnosis of fractures in children. J Bone Joint
Surg Br 2000 Nov; 82(8): 1170-3[Medline]. |
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Keret D, Mendez AA, Harcke HT,
MacEwen GD: Type V physeal injury: a case report. J Pediatr Orthop
1990 Jul-Aug; 10(4): 545-8[Medline]. |
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Lohman M, Kivisaari A, Kallio P:
Acute paediatric ankle trauma: MRI versus plain radiography. Skeletal
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Mac Nealy GA, Rogers LF, Hernandez
R: Injuries of the distal tibial epiphysis: systematic radiographic
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Petit P, Panuel M, Faure F: Acute
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